Transurethral resection of bladder tumor (TURBT) is usually performed in a piecemeal technique. Tumor fragmentation and cell spilling could be responsible for high recurrence rates. Circulating tumor cells (CTCs) have been shown to be a prognostic predictor in disease progression in transitional cell carcinoma. In the current study the investigators aim to quantify CTCs in purging fluid and blood for recurrent intermediate risk bladder cancer during surgery for two different methods: TURBT and Plasma-kinetic vaporization of bladder tumor (PKVBT). Also correlations for recurrence will be investigated for the two different surgical methods.
Age range
18 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
intraoperative CTC-number in blood [n/ml]
Timeframe: During surgery: after evacuation of snippets for TURBT and after full vaporization for PKVBT.
postoperative CTC-number in blood [n/ml]
Timeframe: 2nd postoperative day during morning routine.
postoperative CTC-number in purging fluid [n/ml]
Timeframe: For both gruops (TURBT and PKVB) after insertion of indwelling catheter before finishing surgery.
postoperative CTC morphology in purging fluid
Timeframe: After insertion of indwelling catheter before finishing the surgery.
pre-to-intraoperative change of CTC-number in blood [n/ml]
Timeframe: Preoperative CTCs will be taken right before the start of surgery. Intraoperative CTCs will be taken after evacuation of snippets for TURBT and after full vaporization for PKVBT.
pre-to-postoperative change of CTC-number in blood [n/ml]
Timeframe: Preoperative CTCs will be taken right before the start of surgery. Postoperative CTCs will be taken on day 2 after surgery during the morning routine.
intra-to-postoperative change of CTC-number in blood [n/ml]
Timeframe: Intraoperative CTCs will be taken after evacuation of snippets for TURBT and after full vaporization for PKVBT. Postoperative CTCs will be taken on day 2 after surgery during the morning routine.
pre-to-postoperative change of CTC-number in purging fluid [n/ml]
Timeframe: Preoperative CTCs in purging fluid are taken via an indwelling catheter right before start of the surgery. Postoperative CTCs in purging fluid are taken after insertion of a new indwelling catheter before finishing the surgery.