Noninvasive Measurement of the Cerebral Autoregulation in Neonates and Infants With Complex Congenital Heart Disease

Inclusion Criteria: * term (37-42 weeks gestation) newborns * pre- or postnatally diagnosed critical congenital heard disease (CHD) * admitted to the pediatric cardiac intensive care unit at the Children's Hospital of Tübingen Exclusion Criteria: * birth weight \<2 kg * history of neonatal depression (5-min APGAR\<5, cord blood pH\<7.0, sepsis, or birth asphyxia) * perinatal seizures * evidence of end-organ injury * preoperative cardiac arrest * significant preoperative intracerebral hemorrhage such as grade 3 or 4 intraventricular hemorrhage.