CompletedNot Applicable

Natural Cycle vs. Modified Natural Cycle vs. Artificial Cycle Protocol for Endometrial Preparation.

Vietnam1,428 participantsStarted 2021-03-22

Plain-language summary

Fresh embryo transfer is a routine procedure in vitro fertilization (IVF) treatment. Since the first live birth after an IVF-FET (frozen embryo transfer), recent years have seen a dramatic rise in the number of FET cycles. Three endometrial preparation protocols for frozen-thawed embryo transfer, including artificial, natural, modified natural protocol, have been studied and applied to maximize treatment outcomes. However, those methods are being applied empirically as their efficacy and safety are yet to be determined. The objective of this study is to compare the effectiveness and safety of those protocols.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged of 18 to 45 * Having menstrual cycle duration of 24 to 38 days * Undergoing no more than 3 previous IVF/ICSI - FET cycles * Planning a frozen-thawed embryo transfer * Agreeing to have no more than 2 day 3 and 1 day 5 embryos transferred * Not participating in another IVF study at the same time Exclusion Criteria: * Menopausal/ Anovulatory women * Having contraindication for exogenous hormones administration: breast cancer, risks of venous thromboembolism * Having embryos from in vitro Maturation or oocyte donation or PGT (pre-implantation genetics testings) cycles * Having uterine abnormalities (e.g., adenomyosis, intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus; unremoved hydrosalpinx, endometrial polyp)

What they're measuring

Live birth rate after one frozen embryo transfer cycle

Timeframe: At 24 weeks of gestation

Trial details

NCT IDNCT04804020

SponsorMỹ Đức Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-31