CompletedPhase 4

A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery

Canada8,421 participantsStarted 2022-02-16

Plain-language summary

A Phase IV trial of a hospital policy of Tranexamic acid to reduce transfusion in major non-cardiac surgery.

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. General surgery (esophagectomy, gastrectomy, gastric repair, small bowel repair or resection, ostomy formation, colon/rectum repair or resection, colostomy, splenectomy, hepatectomy, pancreatectomy, resection of abdominal mass)
✓. Orthopedics (hip fracture repair, pelvic fixation, femur repair / fixation, shoulder / humerus open reduction internal fixation, lower extremity amputation)
✓. Spine (vertebrectomy, surgery involving \>/= 3 levels)
✓. Otolaryngology (glossectomy, mandibulectomy, radical laryngectomy)
✓. Thoracic (lung resection or decortication)
✓. Vascular (arterial bypass / endarterectomy / aneurysmorrhaphy involving the aorta or proximal vessels off the aorta)
✓. Gynecology (hysterectomy)
✓. Urology (nephrectomy, cystectomy, prostatectomy, pelvic exenteration)

Proportion of patients transfused RBCs

Timeframe: From date of surgery until the date of hospital discharge, assessed up to 90 days

Incidence of DVT or PE (collectively called venous thromboembolism (VTE)

Timeframe: Within 90 days of surgery

NCT IDNCT04803747

SponsorUniversity of Manitoba

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-03-05