CompletedNot Applicable

Per Oral Versus Intravenous Postoperative Antibiotics After Surgery for Complicated Appendicitis.

Denmark3,193 participantsStarted 2021-04-01

Plain-language summary

The PIPA trial is a prospective, multicentre, cluster randomized cluster crossover non-inferiority study. We aim to test whether a three-day postoperative course of per oral antibiotics is non-inferior to a three-day postoperative course of intravenous antibiotics as standard care after laparoscopic surgery for complicated appendicitis in regards to the risk of postoperative intraabdominal abscess formation within 30-days

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * On cluster level, hospitals with emergency surgical admissions performing laparoscopic appendectomies are eligible for inclusion. * On an individual level, participants are eligible for inclusion if they undergo a laparoscopic appendectomy for appendicitis (both uncomplicated and complicated), are ≥ 18 years of age, and provide a signed written consent form. Exclusion Criteria: * Exclusion criteria are specifically related to the therapy and individual participants will be excluded if they undergo any other procedures than laparoscopic appendectomy during index surgery.

What they're measuring

Intra-abdominal abscess

Timeframe: Assessed at postoperative day 30

Trial details

NCT IDNCT04803422

SponsorZealand University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-05-31

View on ClinicalTrials.gov More Complicated Appendicitis trials