Randomized Trial of Ropivacaine & Bupivacaine for Inflatable Penile Prosthesis

Inclusion Criteria: * Men undergoing 3-piece penile prosthesis placement under general anesthesia at Mayo Clinic - Rochester. * ≥ 18 years old. Exclusion Criteria: * History of opioid exposure within the preceding 90 days prior to surgery (based on patient-report, review of the electronic medical record, and NMP prescribing database review) * Current or prior history of alcohol or drug abuse (illicit or prescription) * History of chronic pain conditions (chronic musculoskeletal pain, fibromyalgia, central sensitization, chronic pelvic pain syndrome, etc.) * History of cardiac arrhythmia or untreated severe cardiovascular disease * Uncontrolled hypertension * Hepatic insufficiency * Renal insufficiency (CKD stage IIIa or greater) * Current anti-platelet or anti-coagulation therapy with plans to continue at the time of prosthesis placement * Poorly controlled diabetes mellitus (defined as HgbA1c \> 8.5 within 30 days of surgery) * Concurrent adjunctive operative procedures planned at the time of penile prosthesis placement (examples: male urethral sling, Peyronie's disease straightening with penile plication or incision/grafting) * Concurrent non-prosthetic surgery planned at the time of penile prosthesis placement (examples: circumcision, hernia repair, hydrocelectomy, etc.) * Planned infrapubic or subcoronal incision at the time of penile prosthesis placement * Patients who will be undergoing prosthesis placement using local, monitored, or spinal anesthesia (i.e. non-gener…