Brazilian Green Propolis Extract (EPP-AF) as an Adjunct Treatment for Hospitalized COVID-19 Patients (BeeCovid2)

Inclusion Criteria: * Older than 18 years; * Diagnosis of coronavirus infection confirmed by polymerase chain reaction - reverse transcriptase testing; * Symptoms started within 14 days of the randomization date Exclusion Criteria: * Pregnant or lactating women; * Known hypersensitivity to propolis; * Propolis use less than 30 days from the randomization date; * Active cancer; * Human immunodeficiency virus carriers; * Patients undergoing transplantation of solid organs or bone marrow or who were using immunosuppressive medications; * Bacterial infection at randomization, sepsis or septic shock related to bacterial infection at randomization; * Impossibility of using the medication orally or by nasoenteral tube; * Known hepatic failure or advanced heart failure (New York Heart Association \[NYHA\] class III or IV). * End Stage Renal Disease (ESRD).