CompletedNot Applicable

Autologous Intraovarian Platelet Rich Plasma Treatment in Women With Poor Ovarian Response

Bulgaria66 participantsStarted 2021-03-16

Plain-language summary

Reproductive age women diagnosed with poor ovarian response (POR) based on Bologna criteria with a history of at least two prior failed ICSI cycle will be recruited for the study. Antral follicle count (AFC), serum anti-mullerian hormone (AMH), and early follicular phase serum follicle stimulating hormone (FSH) levels will determined at baseline. Autologous blood obtained from peripheral vein will be used to prepare PRP following standard protocols and will be injected to both ovaries. Ovarian reserve parameters and ICSI outcomes will be determined.

Who can participate

Age range30 Years – 46 Years

SexFEMALE

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Inclusion Criteria: * Patients diagnosed with POR based on Bologna criteria and with a history of at least two prior failed ICSI cycles * A previous assisted reproductive technology cycle with less than 3 oocytes (conventional stimulation protocol) and AFC \< 7 * The same ovarian stimulation protocol before and after the PRP treatment Exclusion Criteria: * Age over 46 years, * Body mass index (BMI) ≥ 30 kg/m2, * Presence of pregnancy * Uncontrolled endocrine disorders (polycystic ovary syndrome and others) * Parental genetic and chromosomal disorders, * Immunological disorders * Cancer diagnostics

What they're measuring

Oocyte number

Timeframe: 3 months

Oocyte quality

Timeframe: 3 months

Embryo number

Timeframe: 3 months

Embryo quality

Timeframe: 3 months

Fertilization rate

Timeframe: 3 months

Trial details

NCT IDNCT04797377

SponsorNadezhda Women's Health Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-09-04

View on ClinicalTrials.gov More Poor Ovarian Reserve trials