Eighty subjects with FLD were recruited from the endocrinology clinic at Beijing Chao-yang Hospital. All of the following inclusion criteria needed to be met: hepatic fat content (HFC) were upper 5.0% evaluated by upper abdominal MRI proton density fat fraction (MRI-PDFF) examinations, age ≥ 18 years, body mass index (BMI) ≥ 18.5 kg/m2, and stable body weight (change \< ± 10% of body weight) during the last 3 months. Participants underwent an 8-week 5:2 IF intervention. Metabolic parameters and thyroid hormone sensitivity indices were assessed at baseline and after intervention.
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Body Mass Index (BMI, kg/m²) measured using digital scale and stadiometer
Timeframe: 8 weeks
TSH Index (TSHI) calculated from serum TSH and FT4 levels
Timeframe: 8 weeks
Thyrotroph Thyroid Hormone Sensitivity Index (TTSI) calculated from serum TSH and FT4 levels
Timeframe: 8 weeks
FT3/FT4 ratio calculated from serum FT3 and FT4 levels
Timeframe: 8 weeks
Changes in metabolic parameters after 8-week IF intervention, measured using blood tests and biochemical assays.
Timeframe: 8 weeks
Changes in abdominal MRI findings (liver fat deposition) after 8-week IF intervention, assessed using magnetic resonance imaging
Timeframe: 8 weeks