FlowTriever for Acute Massive Pulmonary Embolism (FLAME)

Inclusion Criteria: Age \>=18 years Treatment team determines pulmonary embolism is the cause of shock, and the PE is high-risk per the protocol definitions Exclusion Criteria: * Out of hospital cardiac arrest with Glasgow Coma Scale of ≤8 * Witnessed cardiac arrest with ongoing CPR \>30 minutes * Contraindication to anticoagulants, i.e. heparin or alternative * Hematocrit \<28% * Platelets \<25,000/μL * INR \>8 * Intracardiac thrombus and/or intracardiac clot in transit * Known anaphylactic sensitivity to radiographic agents that cannot be pre-treated * History of pulmonary hypertension with systolic pulmonary arterial pressure \>70 mmHg * Presence of chronic medical conditions with estimated \< 90 days life expectancy per physician discretion (should not consider the current pulmonary embolism and its treatment) * Current participation in another drug or device treatment study that, in the Investigator's opinion, would interfere with participation in this study * Patient is known to be COVID-19 positive at hospital admission (patient has active COVID-19)