Investigating the Consumption of Different Protein Rich Whole Food Sources on Muscle Growth in Tr… (NCT04794153) | Clinical Trial Compass
CompletedNot Applicable
Investigating the Consumption of Different Protein Rich Whole Food Sources on Muscle Growth in Trained Males and Females
United Kingdom66 participantsStarted 2021-05-01
Plain-language summary
Background To date, most of the literature investigating the role of dietary protein in muscle growth has focused on isolated protein sources. However, dietary protein is most commonly consumed within a whole food source. Consuming dietary protein within a whole food matrix may additionally stimulate muscle growth. The idea being, there may be other components within food, capable of producing a greater response.
Objectives: To assess the effect of consuming a variety of whole food sources, on the stimulation of muscle growth compared to an isolated protein source following a single bout of lower body resistance exercise.
Methods Young healthy resistance-trained volunteers will consume a protein rich whole food source, following a bout of lower body resistance exercise. Stable isotope IV infusions and repeated blood and muscle samples will be taken to assess protein digestion and absorption, as well as muscle protein synthesis rates.
Value of Research:
To determine whether whole food sources potentiate muscle protein synthesis rates (and to what extent across whole food sources) compared to an isolated protein source. In doing so, we can further investigate the nutrients involved that may be contributing to this effect.
Who can participate
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Males and Females
* BMI 18.5 - 30 kg/m2
* Aged 18 - 40 years
* Structured Resistance training consistently for \> 6 months
* A 5-7 day "washout" period from any supplementation
Exclusion Criteria:
* Age \>40 years
* Body mass index (BMI) \<18.5 or \>30 kg/m2
* Any metabolic impairments
* Any cardiovascular impairments
* High blood pressure (≥140/90 mmHg)
* Any gastrointestinal disorders
* Any medications known to affect protein and/or amino acid metabolism
* A personal or family history of epilepsy, seizures or schizophrenia, motor disorder
* Chronic over the counter use of pharmaceuticals (\> 1 month)
* Allergic to any of the whole foods included in the study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Postprandial Muscle protein Synthetic Response following the ingestion of a protein rich whole food source.