CompletedNot Applicable

Underlying Mechanisms of Obesity-induced Obstructive Sleep Apnea

United States106 participantsStarted 2021-03-20

Plain-language summary

Obesity is a common risk factor for the development of obstructive sleep apnea. However, not all subjects with obesity develop obstructive sleep apnea. This study will attempt to determine the mechanistic drivers between obesity and obstructive sleep apnea.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * \- Men and women * Ages \>= 18-65 years old * BMI 35 kg/m2--and above * Scheduled for sleeve gastrectomy (bariatric surgery) Exclusion Criteria: * Any cardiovascular, pulmonary or renal disease other than well-controlled hypertension or asthma. * Pregnancy * Currently smoking * Any respiratory disorder other than OSA or well controlled asthma * contraindication to MRI

What they're measuring

muscle traits contributing to OSA in obesity - change is being assessed over time

Timeframe: Time point 1: Within 1 month of bariatric surgery, Time point 2: 6 months following bariatric surgery

changes in pcrit after bariatric surgery

Timeframe: Time point 1: Within 1 month of bariatric surgery, Time point 2: 6 months following bariatric surgery

MRI upper airway changes following bariatric surgery - change is being assessed over time

Timeframe: Time point 1: Within 1 month of bariatric surgery, Time point 2: 6 months following bariatric surgery

Trial details

NCT IDNCT04793334

SponsorBrandon Nokes

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-05-31

View on ClinicalTrials.gov More Obstructive Sleep Apnea trials