CompletedPhase 4

Preemptive Analgesia With Celecoxib for Acute Dental Pain Management

United States65 participantsStarted 2021-04-22

Plain-language summary

The purpose of this study is to compare the effect on postoperative pain of a single agent nonsteroidal anti-inflammatory drug (NSAID) \[celecoxib plus placebo\] to an NSAID combination \[celecoxib plus acetaminophen\] administered preemptively to patients prior to impacted third molar surgery. .

Who can participate

Age range18 Years – 45 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status classification 1 or 2 * at least 1 impacted mandibular third molar planned for extraction Exclusion Criteria: * ASA 3 or higher for physical status classification * severe pericoronitis associated with third molar to be extracted * any known allergies to NSAIDs, aspirin, acetaminophen, sulfa drugs * history of cardiovascular or cerebrovascular disease * hepatic disease or impairment * pregnancy

What they're measuring

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 3 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 8 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 12 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 18 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 24 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 36 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 48 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 72 hours after procedure

Trial details

NCT IDNCT04790812

SponsorThe University of Texas Health Science Center, Houston

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-03-01

Results submitted2024-02-27

View on ClinicalTrials.gov More Pain, Postoperative trials

Who can participate

Age range18 Years – 45 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 3 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 8 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 12 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 18 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 24 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 36 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 48 hours after procedure

Pain as Assessed by a Visual Analogue Scale (VAS)

Timeframe: 72 hours after procedure