Active — Not RecruitingPhase 4

The Impact of Prednisone on Semen Parameters and Pregnancy Rates Post Vasectomy Reversal

United States100 participantsStarted 2021-02-24

Plain-language summary

1. Determine impact of prednisone on semen parameters post vasectomy reversal (evaluated both using prednisone as a combined cohort as well as via 3 separate protocols). 2. Determine impact of prednisone on pregnancy rates post vasectomy reversal (evaluated both using prednisone as a combined cohort as well as via 3 separate protocols). 3. Assess adverse events with prednisone utilization

Who can participate

Age range18 Years – 65 Years

SexMALE

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Inclusion Criteria: * Men undergoing a first-time vasectomy reversal at the Male Fertility and Peyronie's Clinic * 18-65 years of age * Current sexual partner with desire to achieve pregnancy immediately * Intent of reversal to restore fertility * Partner \<36 years of age * Partner with no known fertility issues * Prior history of paternity Exclusion Criteria: * Current corticosteroid use * Prior vasectomy reversal * Prior chemotherapy * Testosterone use within 1 year of the vasectomy reversal * Solitary testicle * History of diabetes mellitus * History of systemic fungal infection * Hypertension * Any degree of diagnosed renal insufficiency * Partner on birth control within past 3 months

What they're measuring

Impact of Prednisone on semen concentration post vasectomy reversal

Timeframe: 3 years

Impact of prednisone on pregnancy rates post vasectomy reversal.

Timeframe: 3 Years

Assess adverse events with prednisone utilization

Timeframe: 3 years

Trial details

NCT IDNCT04788823

SponsorCharitable Union for the Research and Education of Peyronie's Disease

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-02

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