CompletedPhase 2

Minimally Invasive Flap With Platelet Rich Fibrin or Growth Factor Enhanced Matrix in Treatment of Intrabony Defect

Egypt21 participantsStarted 2018-01-01

Plain-language summary

Twenty-one intra-bony defects in fifteen systemically healthy patients with moderate to severe chronic periodontitis were randomly classified into 3 groups, 7 sites each. Group І treated by MIST alone, group ІІ treated by MIST + ethylenediamine-tetraaceticacid (EDTA) + PRF and group III treated by MIST + EDTA + GEM 21S. The clinical parameters including probing pocket depth (PPD), clinical attachment level (CAL) and bleeding on probing (BOP), were recorded at baseline, 3, 6 and 9 months post-surgery. Cone beam computed tomography (CBCT) was performed at baseline and 9 months post-surgery to evaluate bone level and bone density

Who can participate

Age range30 Years – 55 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: • Presence of at least one tooth with PPD and CAL loss of ≥ 5 mm associated with an intra-bony defect of ≥ 2 mm according to Cortellini and Tonetti, 2007 Exclusion Criteria: * Patients with uncontrolled or poorly controlled diabetes, life-threatening conditions, or requiring antibiotic prophylaxis were excluded. * Smokers * Pregnant patients. * Patients with aggressive periodontitis. * Patients with multiple interconnected vertical defect walls.

What they're measuring

the change in probing pocket depth

Timeframe: 9 months

the change bleeding on probing score

Timeframe: 9 months

the change Clinical attachment level

Timeframe: 9 months

Cone beam radiograph

Timeframe: 9 months

Trial details

NCT IDNCT04786327

SponsorTanta University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-10-01

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