Proof of Concept Study of SAR443122 in Patients With Cutaneous Lupus Erythematosus

Inclusion criteria : * Participants with cutaneous lupus erythematosus either in the form of discoid/chronic cutaneous lupus erythematosus or subacute cutaneous lupus erythematosus for at least 3 months before Screening. * Participants with histologically confirmed and documented diagnosis within one year prior to Screening or during Screening period prior to randomization. * Active cutaneous lupus erythematosus skin lesions and a Cutaneous Erythematosus. * Disease Area and Severity Index activity (CLASI-A) ≥10 both at Screening and Baseline. * Participant who was candidate for systemic treatment per Investigator's judgement. Exclusion criteria: * Systemic lupus erythematosus according to the 2012 SLICC criteria with major organ involvement. * Suspected or proven drug induced lupus erythematosus, including patients with positive antihistone autoantibody tests. * Autoimmune disease(s) other than systemic lupus erythematosus. * Active skin diseases that may interfere with the study or study assessments. * Exclusion related to tuberculosis, non-tuberculous mycobacterial infections, HIV, HBV, HCV, Herpes zoster, COVID-19 and other recurrent or recent serious infections. * Prolonged QTcF ≥ 450 ms (by Fridericia formula) or clinically significant findings on electrocardiogram (ECG). * Cannot avoid excessive UV exposure 4 weeks prior to baseline and during the study. Routine sun exposure through work are permitted but requires the use of sun block to sun exposed areas for at leas…