The aim of this study is to compare the effect of the liberal and restrictive fluid treatments which are routinely performed in major urological surgeries in the perioperative period on ANP release and the endothelial glycocalyx layer. In the study, the investigators aimed to compare changes in the glycocalyx structure by measuring the blood levels of ANP and heparan sulfate, hyaluronan and syndecan 1, which form the glycocalyx structure on the patients who received the liberal and restrictive fluid treatments during major urological surgeries.
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Atrial Natriuretic Peptide (ANP)( pg/mL)
Timeframe: The blood sample will be taken at beginning and end of the surgery
Heparan sulfate (ng/L)
Timeframe: The blood sample will be taken at beginning and end of the surgery
Syndecan 1 (pg/mL)
Timeframe: The blood sample will be taken at beginning and end of the surgery
Hyaluronan (ng/L)
Timeframe: The blood sample will be taken at beginning and end of the surgery