A Combined Microdialysis and FDG-PET Study for Detection of Brain Injury After Cardiac Arrest

Inclusion Criteria: * Out-of-hospital cardiac arrest (OHCA) of presumed cardiac cause * Sustained return of spontaneous circulation (ROSC), defined as ROSC when chest compressions have not been required for 20 consecutive minutes and signs of circulation persist * Unconsciousness (Glasgow Coma Scale (GCS) score of less than 8) after sustained ROSC * Target temperature management (TTM) is indicated. Exclusion Criteria: * Conscious patient (GCS score of at least 8) * Female of child-bearing potential, unless a negative human chorionic gonadotropin (hCG) test can rule out pregnancy within the inclusion window * In-hospital cardiac arrest (IHCA) * OHCA of presumed non-cardiac cause, such as after trauma, dissection/rupture of major artery or arrest caused by hypoxia (i.e., drowning, hanging, etc.) * Known bleeding diathesis (medically induced coagulopathy does not exclude patient) * Suspected or confirmed acute intracranial bleeding * Suspected or confirmed acute ischemic stroke * Unwitnessed asystole * Known limitations in therapy and do-not-resuscitate order