UnknownNot Applicable

Comparison of Posterior Ocular Changes Between Singleton Pregnancy and Multifetal Pregnancy.

Thailand166 participantsStarted 2021-09-03

Plain-language summary

It has been known that a pregnant women undergoes significant anatomical and physiological changes that mainly caused by hormonal and hematologic changes during pregnancy. Due to advance in reproductive medicine, the incidence of multifetal pregnancy was increased to 3% of livebirth. Multifetal pregnancies produce much more physiological changes in the body compared to the singleton pregnancies. Physiologic ocular changes during pregnancy are the followings * Melanogenesis of eyelid and facial skin * Cellular alteration of lacrimal and meibomian gland * Increased corneal thickness and corneal curvature * Increased lens thickness * Increased retinal vascular density * Increased choroidal thickness Decreased intraocular pressure -

Who can participate

Age range

24 Years – 37 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 24-37 years * 30-36 weeks of gestational age * clear ocular media * written informed consent Exclusion Criteria: * high risk pregnancies such as pre-eclampsia, gestational diabetic mellitus and asthma * history of refractive error, spherical equivalent \> 3 diopters * history of retinal diseases such as central serous chorioretinopathy and retinal vascular occlusion * history of intraocular inflammation or endophthalmitis * history of intraocular laser treatment * history of intraocular surgery

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Choroidal thickness

Timeframe: 30-36 weeks of gestational age

Trial details

NCT IDNCT04773561

SponsorKhon Kaen University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-30

Contact for this trial

Suthasinee Sinawat, MD

+66815454594 ssuthasinee@kku.ac.th

View on ClinicalTrials.gov More Twin Pregnancy, Antepartum Condition or Complication trials