CompletedNot Applicable

DNA Damage in Critically Ill COVID-19 Patients

Czechia10 participantsStarted 2020-11-23

Plain-language summary

Critically ill patients with COVID-19 are exposed to high oxidative stress which is potential harm to the DNA. Peripheral lymphocytes' DNA will be investigated using the comet assay on changes in oxidative damage to the purine and pyrimidine bases and single-stranded DNA breaks.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * critically ill adult patient admitted to ICU with positive RT-PCR test or bed-side antigen test on COVID-19 with signs and symptoms of organ failure * informed consent Exclusion Criteria: * rejection by the patient to sign an informed consent

What they're measuring

single-stranded DNA breaks

Timeframe: One week

oxidation of DNA bases

Timeframe: One week

Trial details

NCT IDNCT04772703

SponsorUniversity Hospital Hradec Kralove

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-02-28

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