The investigator's purpose is to study the population pharmacokinetics of commonly used antimicrobial agents in children of bacterial meningitis with augmented renal clearance and assess dosage individualization feasibility.
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The peak plasma and cerebrospinal fluid drug concentration of meropenem,vancomycin,ceftazidime,ceftriaxone,ceftizoxime,linezolid.
Timeframe: at (5-10) minutes after intravenous administration
The random plasma and cerebrospinal fluid drug concentration of meropenem,vancomycin,ceftazidime,ceftriaxone,ceftizoxime,linezolid.
Timeframe: at (0.5-10) hours after intravenous administration
The trough plasma and cerebrospinal fluid drug concentration of meropenem,vancomycin,ceftazidime,ceftriaxone,ceftizoxime,linezolid.
Timeframe: at 1-2 hours before the next administration