RecruitingNot Applicable

Genetic Studies of Strabismus, Nystagmus, and Associated Disorders

United States400 participantsStarted 2021-09-03

Plain-language summary

Strabismus (misalignment of the eyes) often runs in families. In this study, the investigators are looking for genetic variants associated with strabismus and nystagmus. Three types of subects will be enrolled: (1) Families with at least 3 members with strabismus, (2) individuals with infantile esotropia and their parents and siblings, and (3) individuals with infantile nystagmus and their parents. Whole exome and/or whole genome sequencing will be used to identify genetic variants shared by family members with strabismus and to identify genetic causes of nystagmus.

Who can participate

SexALL

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Inclusion Criteria: \- Member of a family with at least 3 biological relatives with strabismus. (Both affected and non-affected family members will be enrolled). OR \- Member of a family with at least 1 individual with infantile esotropia. (Both affected and non-affected family members will be enrolled). OR \- Member of a family with at least 1 individual with infantile nystagmus. (Both affected and non-affected family members will be enrolled). Exclusion Criteria: * paralytic strabismus in affected family members

What they're measuring

Genetic variants

Timeframe: 2 years

Trial details

NCT IDNCT04770519

SponsorBoston Children's Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2030-12

Contact for this trial

Kayleen Cremin, BA

857-292-3768 research.whitman@childrens.harvard.edu

View on ClinicalTrials.gov More Strabismus trials