Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).

Inclusion Criteria: * Age: 25 to 55 years. * Gender: Both males and females will be included in the study. * Co-operative and motivated patients committed to oral hygiene. * Patients exhibiting intrabony defects. Exclusion Criteria: * Patients with contraindication to periodontal surgery \& local anesthesia. * Any systemic disease affecting the bone density and outcome of periodontal therapy. * Smokers, alcoholics, and patients with other adverse habits. * Pregnant, nursing and menopausal women. * Any known allergy/ hypersensitivity to any product used in this study. * Patients on long-term systemic therapy (antibiotics, anti-inflammatory bisphosphonates, hormonal replacement therapy and any other), taking any drug known to have periodontal implications that may interfere with wound healing. * Patients taking any anti-platelet and anticoagulant medication. * Patients who have undergone periodontal treatment within a period of past 1 year.