Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®). (NCT04767243) | Clinical Trial Compass
CompletedPhase 4
Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).
India48 participantsStarted 2020-12-01
Plain-language summary
The aim of this study is to evaluate and compare the regenerative potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of intrabony defects in chronic periodontitis patients.
Who can participate
Age range
25 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age: 25 to 55 years.
* Gender: Both males and females will be included in the study.
* Co-operative and motivated patients committed to oral hygiene.
* Patients exhibiting intrabony defects.
Exclusion Criteria:
* Patients with contraindication to periodontal surgery \& local anesthesia.
* Any systemic disease affecting the bone density and outcome of periodontal therapy.
* Smokers, alcoholics, and patients with other adverse habits.
* Pregnant, nursing and menopausal women.
* Any known allergy/ hypersensitivity to any product used in this study.
* Patients on long-term systemic therapy (antibiotics, anti-inflammatory bisphosphonates, hormonal replacement therapy and any other), taking any drug known to have periodontal implications that may interfere with wound healing.
* Patients taking any anti-platelet and anticoagulant medication.
* Patients who have undergone periodontal treatment within a period of past 1 year.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
probing depth
Timeframe: baseline, 3 months, 6 months
2
relative attachment level
Timeframe: baseline, 3 months, 6 months
3
radiographic linear bone change
Timeframe: change from baseline to 6 months
Trial details
NCT IDNCT04767243
SponsorMaharishi Markendeswar University (Deemed to be University)