Evaluate the Efficacy and Safety of the ADVAGRAF® (NCT04763096) | Clinical Trial Compass
CompletedPhase 4
Evaluate the Efficacy and Safety of the ADVAGRAF®
South Korea101 participantsStarted 2016-11
Plain-language summary
The primary objective of this study is to evaluate the efficacy of 6-month treatment with Advagraf® converted from 12-month treatment with tacrolimus in stable liver transplant recipients.
The secondary objective of this study is to evaluate severity of acute rejection confirmed by biopsy in 24 weeks, incidence of chronic rejection, patient and graft survival rates in 24 weeks, incidence of adverse events, blood pressure, tacrolimus trough level, drug compliance, and adherence.
Who can participate
Age range19 Years – 80 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
âś“. Aged between 19 and 80 years old
âś“. Those who were transplantated liver at a minimum of 12 month of screening and after 12 month Treatment with a Tacrolimus stably.(Brain dead transplantation or biological transplant no values)
âś“. tacrolimus blood everage level is 3-10 ng/ml for at least 6 months prior to screening.
âś“. Female subjects of child bearing potential must have a negative urine or serum pregnancy test prior to enrollment and at the end of study and must agree to practice effective birth control during the study.
âś“. Subjects are stable clinically in the opinion of the investigator.
âś“. Subjects capable of understanding the purpose and risks of the study, having been fully informed and has given written informed consent to participate in the study
Exclusion criteria
âś•. Subjects having previously received an organ transplant excluding liver transplant. Or Subjects receiving an auxiliary graft or in whom a bio-artificial liver(cell system) has been used.
âś•. Acute rejection confirmed by histologic response or the patient had chronic rejection
âś•. Subjects diagnosed new malignant tumor before the pre-screening within five years , with the exception of basalioma or squamous cell carcinoma or carcinoma in situ of the skin that has been treated successfully.
âś•. Subjects allergic to tacrolimus or investigational product.
What they're measuring
1
Incidence of acute rejection confirmed by biopsy in 24 weeks after conversion
. Subjects are unstable clinically state in the opinion of the investigator.
âś•. Subjects with any form of substance abuse, psychiatric disorder or condition which, in the opinion of the investigator, may complicate communication with the investigator.
âś•. Subjects participating or having participated in another clinical trial and/or those taking or having taken an investigational / non-registered drug in the past 28 days.
âś•. Subjects taking forbidden concomitant medications or within 28 days prior to enroll.