Study of a Geriatric Assessment to Plan a Treatment Approach for Older People With Various Blood Disorders

Inclusion Criteria: * are 60 years or older * have a pathologically confirmed myeloid malignancies including acute myeloid leukemia, ,myelodysplastic syndrome, myeloproliferative neoplasms, or related blood disorders including chronic myelomonocytic leukemia, atypical chronic myeloid leukemia, and myelodysplastic/myeloproliferative overlapping syndrome * have \<10% blasts in bone marrow prior to transplant * have a matched related or unrelated donor, mismatched unrelated donor, or haploidentical donor * Meet institutional standard criteria for allogeneic transplantation as determined by the primary transplant physician * Undergoes transplantation using the allocated conditioning regimen intensity defined by the protocol-specified criteria below: * HCT-CI/Age \<5 and IADL normal = myeloablative regimen * HCT-CI/Age ≥5 and/or IADL impairment = RIC/NMA regimen Exclusion Criteria: * Prior hematopoietic cell transplantation * Cord blood donors * Persons with active, refractory disease defined by ≥10% blasts in bone marrow prior to transplant