CompletedPhase 1

The Clinical Impact of L-PRF, H-PRF or the Use of Surgical Stent on Palatal Donor Site Healing.

United States30 participantsStarted 2021-02-24

Plain-language summary

A Randomized, Three Parallel Arms Clinical Trial to evaluate s the clinical impact of L-PRF vs H-PRF vs Palatal stent on the healing of the donor palatal site.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Subjects between 18-65 years of age.
. Subjects need FGG or de-epithelialized Connective tissue graft
. Good oral hygiene (Plaque and bleeding indexes \<20%).
. Subjects can withstand alginate impression or wear a retainer.
. No other surgery or need for analgesics at the same site.

Exclusion criteria

. Subjects with any systemic disorders that might compromise wound healing (Uncontrolled diabetes mellitus, rheumatoid arthritis, osteoporosis, chemotherapy/radiotherapy and immunological disorders).
. Smokers
. Patients not maintaining oral hygiene (plaque score \>20%)
. Pregnant or breastfeeding females.
. Inability to provide informed consent.
. Grafts thickness more than 2mm will be excluded from the study.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The Clinical Impact of L-PRF, H-PRF, or the Use of a Surgical Stent on Palatal Donor Site Healing.

Timeframe: 5 days

The Clinical Impact of L-PRF, H-PRF, or the Use of a Surgical Stent on Palatal Donor Site Healing.

Timeframe: 10 days

The Clinical Impact of L-PRF, H-PRF, or the Use of a Surgical Stent on Palatal Donor Site Healing.

Timeframe: 14 days

The Clinical Impact of L-PRF, H-PRF, or the Use of a Surgical Stent on Palatal Donor Site Healing.

Timeframe: 21 days

Trial details

NCT IDNCT04758702

SponsorAbdo Y Ismail

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-05-25

View on ClinicalTrials.gov More Lack of Keratinized Gingiva trials

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Subjects between 18-65 years of age.
. Subjects need FGG or de-epithelialized Connective tissue graft
. Good oral hygiene (Plaque and bleeding indexes \<20%).
. Subjects can withstand alginate impression or wear a retainer.
. No other surgery or need for analgesics at the same site.

Exclusion criteria

. Subjects with any systemic disorders that might compromise wound healing (Uncontrolled diabetes mellitus, rheumatoid arthritis, osteoporosis, chemotherapy/radiotherapy and immunological disorders).
. Smokers
. Patients not maintaining oral hygiene (plaque score \>20%)
. Pregnant or breastfeeding females.
. Inability to provide informed consent.
. Grafts thickness more than 2mm will be excluded from the study.

What they're measuring

The Clinical Impact of L-PRF, H-PRF, or the Use of a Surgical Stent on Palatal Donor Site Healing.

Timeframe: 5 days

The Clinical Impact of L-PRF, H-PRF, or the Use of a Surgical Stent on Palatal Donor Site Healing.

Timeframe: 10 days

The Clinical Impact of L-PRF, H-PRF, or the Use of a Surgical Stent on Palatal Donor Site Healing.

Timeframe: 14 days

The Clinical Impact of L-PRF, H-PRF, or the Use of a Surgical Stent on Palatal Donor Site Healing.

Timeframe: 21 days