Remote Ischemic Conditioning for Cerebral Amyloid Angiopathy-related Intracerebral Hemorrhage
China30 participantsStarted 2021-02-24
Plain-language summary
Cerebral amyloid angiopathy-related intracerebral (CAAH) hemorrhage is second factor of primary intracerebral hemorrhage. However, no effective prevention and treatment strategies have been established. Remote ischemic conditioning is a neuroprotective strategy. In animal studies，RIC is efficiency in accelerating the absorption of hematoma. Therefore, the investigators plan to carry out this research to evaluate the safety and efficacy of RIC in patients with CAA related ICH.
Who can participate
Age range55 Years – 85 Years
SexALL
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Inclusion Criteria:
* Age≥55 and ≤85.
* The diagnosis of single or multiple spontaneous lobar cerebral hemorrhage is confirmed by brain CT scan(defined as possible or probable CAA by the Boston criteria) .
* Hematoma volume of 10 to 50 ml.
* Glasgow Coma Score (GCS)\>8.
* Without surgery.
* Starting RIC treatment between 24 and 48 hours of ictus.
* Signed and dated informed consented is obtained.
Exclusion Criteria:
* Patients with suspected secondary ICH related to tumor, coagulopathy, ruptured aneurysm or arteriovenous malformation, or venous sinus thrombosis.
* ICH concomitant with intraventricular hemorrhage, subdural hematoma, epidural hematoma subarachnoid hemorrhage or the condition of unstable vital signs which may be life-threatening.
* Evidence of significant shift of midline brain structure (\>5mm) or herniation on brain imaging.
* Contraindication to MRI scan, such as intracranial metal implants, cardiac pacemaker, severe claustrophobia, history of seizures and so on
* Patients with a pre-existing neurological deficits (modified Ranks scale score \>2) or psychiatric disease that would confound the neurological or functional evaluations.
* Use of warfarin or heparin within 7 days before the baseline visit
* Contraindication for remote ischemic conditioning: severe soft tissue injury, limb deformities, fracture, atrial fibrillation or peripheral vascular disease in the upper limbs.
* Life expectancy of less than 1 year due to co-morbid conditions.
* Severe, susta…