Multi-agent Low Dose Chemotherapy GAX-CI Followed by Olaparib and Pembro in Metastatic Pancreatic Ductal Cancer.

Inclusion Criteria: * Cohort 1 - Subject has stable disease as measured by RECIST 1.1 or iRECIST after 6 cycles of GAX-CI. * Cohort 2 - Subject has progressive disease as measured by RECIST 1.1 and iRECIST prior to 6 cycles of GAX-CI. * Ability to understand and willingness to sign a written informed consent document. * Age ≥18 years. * Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 * Have metastatic histologically or cytologically-proven ductal pancreatic cancer. * Patients must not have received prior treatment for pancreatic cancer. * Have measurable disease based on RECIST 1.1. * Willing to have to a tumor biopsy. * Patients must have adequate organ and marrow function defined by study - specified laboratory tests. * Woman of childbearing potential must have a negative pregnancy test and follow contraceptive guidelines as defined per protocol. * Men must use acceptable form of birth control while on study. * Participant understands the study regimen, its requirements, risks and discomforts, competent to report AE, understand the drug dosing schedule and use of medications to control AE. Exclusion Criteria: * Patients who will be considered for surgery are ineligible. * Had chemotherapy within 5 years prior to study treatment. * Have received any investigational drugs within 28 days prior to study treatment. * Had surgery within 28 days of dosing of investigational agent. * Has history of central nervous system (CNS) metastases and/or carcinomatous …