Liposomal Bupivacaine Versus Bupivacaine Plain for Operative Pain Management of Forefoot Surgery

Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Male or female, greater than 18 years of age * ASA Class I or II * Ability to take oral medication in order to assess the patient's opioid regimen postoperatively * Forefoot surgery, including bunionectomy +/- digital surgery * For females of reproductive potential: hCG levels will be determined during the pre-operative period. Females of childbearing age require a hCG level below 5mIU/mL in order to participate in the study. hCG levels above 25 mIU/mL is considered positive for pregnancy and, as a result, the patient will not be considered eligible for inclusion in the study Exclusion Criteria: * Chronic users of opioids, use for greater than 14 days in the last 3 months or nonopioid pain medications for more than 5 times per week * Prescription for SSRIs, gabapentin, duloxetine within 3 days of surgery * Systemic glucocorticoids within 1 month of study enrollment * History of hepatitis * History of peripheral vascular disease * History of diabetes mellitus type 1 or 2 * Pregnancy or lactation * Allergic to opioids * Known allergic reactions to components of the bupivacaine injectable or other amide anesthetics; the allergen may involve preservative compounds such as methylparaben used in the preparation of amide-type agents are metabolized to PABA * BMI \> 40