CompletedPhase 4

Does PAI Reduce Pain After TKA Among Knee Arthroplasty Patients Receiving ACB & IPACK?

United States94 participantsStarted 2020-12-17

Plain-language summary

The goal of this clinical trial is to determine whether Periarticular Injection (PAI) alongside Adductor Canal Block (ACB) and Infiltration between the Popliteal Artery and Capsule of the Knee (IPACK) block can decrease post-operative pain in patients undergoing primary total knee arthroplasty. The main question it aims to answer is: • Is ACB/IPACK without PAI as effective as ACB/IPACK with PAI for TKA patients? Participants will be assigned to one of the following groups at random: * ACB/PACK with PAI * ACB/IPACK with saline injection Participants will also be asked to complete pre- and post-operative questionnaires.

Who can participate

Age range25 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Planned use of regional anesthesia * Ability to follow the major components of the study protocol * English speaking (Secondary outcomes include questionnaires validated in English only) Exclusion Criteria: * Patients younger than 25 years old and older than 80 * Non-English speaking * Patients intending to receive general anesthesia * Contraindication to nerve blocks or peri-articular injection * Patients with an ASA of IV or higher * Renal insufficiency (ESRD, HD, estimated creatinine clearance \< 30 ml/min) * Patients with major prior ipsilateral open knee surgery * Chronic gabapentin/pregabalin use (regular use for longer than 3 months) * Chronic opioid use (taking opioids for longer than 3 months)

What they're measuring

Pain Scores (NRS, 0-10) With Ambulation on POD1

Timeframe: 24 hours Post Operative Discharge

Trial details

NCT IDNCT04749615

SponsorHospital for Special Surgery, New York

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-04-01

Results submitted2024-02-22