Active — Not RecruitingNot Applicable

Immediate Versus Postponed Single Blastocyst Transfer in mNC-FET

Denmark464 participantsStarted 2021-04-01

Plain-language summary

The purpose of this randomized controlled trial is to investigate if immediate single blastocyst transfer (in the first menstrual cycle following oocyte retrieval) is non-inferior to standard postponed single blastocyst transfer (in the second or subsequent menstrual cycle following oocyte retrieval) in modified natural cycle frozen-thawed embryo transfer (mNC-FET) in terms of live birth rate.

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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Inclusion Criteria: * Patients eligible for FET in a modified natural cycle * Regular menstrual cycle (23-35 days) * Vitrified day 5 or 6 blastocyst * Blastocyst Gardner score \> or = 3BB at the day of vitrification Exclusion Criteria: * Uterine malformations or presence of hydrosalpinx * Submucosal uterine myomas * Uterine polyps * Allergy to standard fertility medication * Contradiction to standard fertility medication * Male of female HIV, hepatitis B or C * Preimplantation Genetic Testing (PGT) in the fresh cycle * Severe OHSS during the fresh cycle (defined as need for ascites drainage and/or hospital admission) * Oocyte donation * Testicular sperm aspiration (TESA)

What they're measuring

Live birth rate per randomized patient

Timeframe: One-year follow-up after a positive pregnancy test

Live birth rate per protocol

Timeframe: One-year follow-up after a positive pregnancy test

Trial details

NCT IDNCT04748874

SponsorRigshospitalet, Denmark

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-02

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