Cognitive Behavioral Therapy (CBT) Study Evaluating the Updating of Persecutory Beliefs (NCT04748679) | Clinical Trial Compass
CompletedNot Applicable
Cognitive Behavioral Therapy (CBT) Study Evaluating the Updating of Persecutory Beliefs
United States62 participantsStarted 2021-03-30
Plain-language summary
The purpose of this study is to examine how Bayesian belief updating changes throughout psychotherapeutic treatment for persecutory delusions. Specifically, individuals with a psychotic disorder diagnosis who endorse both a current persecutory delusion with strong conviction and significant worry will be recruited and randomized to receive either a CBT-based worry intervention for persecutory delusions or an active control condition (befriending therapy). The investigators will examine: 1) whether belief updating parameters change as delusion severity changes, 2) whether CBT contributes to greater change in belief updating parameters than befriending therapy, and 3) whether neural correlates of belief updating parameters, as measured using functional magnetic resonance imaging (fMRI), predict treatment response.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion criteria
✓. Men and women age 18 - 65.
✓. Communicative in English.
✓. Premorbid Intelligence \>79 (WTAR)
✓. Provide voluntary, written informed consent.
✓. Physically healthy by medical history.
✓. Weight \<300 lbs
✓. Stable medication regimen over at least the past two weeks, including the use of either an oral or intramuscular administration of an antipsychotic medication.
✓. Diagnosis of a non-affective psychotic disorder (schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, brief psychotic disorder, psychosis NOS) confirmed by Structured Clinical Interview for Diagnostic and Statistical Manual (DSM)-5 (SCID) or diagnostic interview with a trained clinician.
Exclusion criteria
✕. Age less than 18 or greater than 65.
What they're measuring
1
Computational Parameters of Belief Updating as Measured During a Probabilistic Reversal Learning Task
Timeframe: Baseline, 4 weeks, 8 weeks, 24 weeks
2
Change in Delusion Severity Utilizing the Change in Psychotic Symptoms Rating Scale (PSYRATS)
Timeframe: Baseline, 4 weeks, 8 weeks, 24 weeks
3
Change in Neural Correlates of Belief Updating Parameters