CompletedNot Applicable

Eye Gaze Strategies During Facial Emotion Recognition in Neurodegenerative Diseases: Links With Neuropsychiatric Disorders (EYE-ToM Study)

74 participantsStarted 2015-07-01

Plain-language summary

It is commonly admitted that social cognition impairment, like deficit in facial emotion recognition or misinterpretation of others' intentions (Theory of Mind), are associated with social behavior disorders. This kind of disorders are observed in Fronto-Temporal Dementia (FTD), Alzheimer's Dementia (AD) and Parkinson's Disease (PD), with severe deficits in FTD and lighter deficits in AD and PD. One explanation might be that patients apply inappropriate visual exploration strategies to decode emotions and intentions of others. This study aims to test this hypothesis and further to analyse whether different patterns emerge from these pathologies.

Who can participate

Age range

45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Hospitalized or coming to perform a consultation, for whom an Eye-Tracking examination is indicated as part of routine care. * Sufficient written and oral expression in French. * Written informed consent signed by the patient. * For the control group: No cognitive impairment (non pathological MMSE (according to age, gender and socio-cultural level), no neurological history, and no psychiatric history (especially anxiety and depressive disorders). * For the FTD group: Patient diagnosed according to revised Rascovsky et al. 2011., no neurological history (excepted diagnosed FTD), and no psychiatric history (excepted those related to diagnosed FTD). * For the AD group: Patient diagnosed according to DSM-IV-TR criteria, no neurological history (excepted diagnosed AD), and no psychiatric history (excepted those related to diagnosed AD). * For the PD group: Patient diagnosed according to NINDS criteria, no neurological history (excepted diagnosed PD), and no psychiatric history (excepted those related to diagnosed PD). Exclusion Criteria: * General anaesthesia within 3 months. * Ophthalmological problems preventing a video-oculography examination. * Oculomotor disorders such as "fixation disorders" or "ocular tracking disorders". * Cognitive disorders of the type: visual agnosia, visuo-spatial disorder, visuo-perceptual disorder or aphasia. * History of stroke. * History of alcohol or drug abuse.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Eye gaze strategies (number of eye fixation) during Affective Theory of Mind (ToM)

Timeframe: Baseline

Eye gaze strategies (duration of eye fixations) during Affective Theory of Mind (ToM)

Timeframe: Baseline

Eye gaze strategies (response times) during Affective Theory of Mind (ToM)

Timeframe: Baseline

Eye gaze strategies (number of eye fixation) during Facial emotion recognition (FER)

Timeframe: Baseline

Eye gaze strategies (duration of eye fixation) during Facial emotion recognition (FER)

Timeframe: Baseline

Eye gaze strategies (response times) during Facial emotion recognition (FER)

Timeframe: Baseline

Trial details

NCT IDNCT04748263

SponsorCentre Hospitalier Princesse Grace

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-12-01

View on ClinicalTrials.gov More Alzheimer's Dementia trials

Plain-language summary

Who can participate

Age range

45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Eye gaze strategies (number of eye fixation) during Affective Theory of Mind (ToM)

Timeframe: Baseline

Eye gaze strategies (duration of eye fixations) during Affective Theory of Mind (ToM)

Timeframe: Baseline

Eye gaze strategies (response times) during Affective Theory of Mind (ToM)

Timeframe: Baseline

Eye gaze strategies (number of eye fixation) during Facial emotion recognition (FER)

Timeframe: Baseline

Eye gaze strategies (duration of eye fixation) during Facial emotion recognition (FER)

Timeframe: Baseline

Eye gaze strategies (response times) during Facial emotion recognition (FER)

Timeframe: Baseline