CIDP, a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. New CIDP phenotypes without antibodies but with modified cell profiles have been described. Treatments include corticotherapy, IVIg and plasmapheresis but the latter's action mechanisms remain unclear. Plasmapheresis supposedly removes toxic agents like antibodies from plasma but it is uncertain whether it has an immune-modulating effect. Also, the refining mechanisms of the two main plasmapheresis techniques - single plasma exchange and double filtration plasmapheresis (DFPP) - are different and unclear. This study aims to compare the evolution of peripheral lymphocyte profiles in patients with CIDP according to their treatment (single centrifugation plasmapheresis or DFPP) to better grasp the action mechanisms of both techniques.
Age range
18 Years
Sex
ALL
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Cycle 1, Group A : TH1 cells BEFORE single plasma exchange
Timeframe: Day 0, Time 0
Cycle 1, Group A : TH1 cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 1, Group A : TH1 cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7 -10
Cycle 1, Group A : TH17 cells BEFORE first single plasma exchange
Timeframe: Day 0, Time 0
Cycle 1, Group A : TH17 cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 1, Group A : TH17 cells 7 - 10 days AFTER single plasma exchange
Timeframe: Day 7 - 10
Cycle 1, Group A : T-reg cells BEFORE first single plasma exchange
Timeframe: Day 0, Hour 0
Cycle 1, Group A : T-reg cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 1, Group A : T-reg cells 7 - 10 days AFTER single plasma exchange
Timeframe: Day 7 - 10
Cycle 1, Group B : TH1 cells BEFORE first double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 1, Group B : TH1 cells AFTER the first double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 1, Group B : TH1 cells 7-10 days AFTER the first double filtration plasmapheresis
Timeframe: Day 7 - 10
Cycle 1, Group B : TH17 cells BEFORE the first double filtration plasmapheresis
Timeframe: Day0, Hour 0
Cycle 1, Group B : TH17 cells AFTER the first double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 1, Group B : T17 cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7-10
Cycle 1, Group B : T-reg cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 1, Group B : T-reg cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 1, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7 - 10
Cycle 2, Group A: TH1 cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 2, Group A: TH1 cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 2, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7 - 10
Cycle 2, Group A: TH17 cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 2, Group A: TH17 cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 2, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7-10
Cycle 2, Group A: T-reg cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 2, Group A: T-reg cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 2, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7-10
Cycle 2, Group B: TH1 cells BEFORE single plasma exchange
Timeframe: Day 0, Hour 0
Cycle 2, Group B: TH1 cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 2, Group B: TH1 cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7-10
Cycle 2, Group B: T17 cells BEFORE single plasma exchange
Timeframe: Day 0, Hour 0
Cycle 2, Group B: TH17 cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 2, Group B: TH17 cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7-10
Cycle 2, Group B: T-reg cells BEFORE single plasma exchange
Timeframe: Day 0, Hour 0
Cycle 2, Group B: T-reg cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 2, Group B: T-reg cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7-10
Cycle 3, Group A: TH1 cells BEFORE single plasma exchange
Timeframe: Day 1, Hour 1
Cycle 3, Group A: TH1 cells AFTER single plasma exchange
Timeframe: Day 1, Hour 3
Cycle 3, Group A: T1 cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7 - 10
Cycle 3, Group A: TH17 cells BEFORE single plasma exchange
Timeframe: Day 1, Hour 1
Cycle 3, Group A: TH17 cells AFTER single plasma exchange
Timeframe: Day 1, Hour 3
Cycle 3, Group A: TH17 cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7 - 10
Cycle 3, Group A: T-reg cells BEFORE single plasma exchange
Timeframe: Day 0, Hour 0
Cycle 3, Group A: T-reg cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 3, Group A: T-reg cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7-10
Cycle 3, Group B: TH1 cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 3, Group B: TH1 cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 3, Group B: TH1 cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7-10
Cycle 3, Group B: TH17 cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 3, Group B: TH17 cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 3, Group B: TH17 cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7-10
Cycle 3, Group B: T-reg cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 3, Group B: T-reg cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 3, Group B: T-reg cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7-10
Cycle 4, Group A: T1 cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 4, Group A: T1 cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 4, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7 - 10
Cycle 4, Group A: TH17 cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 4, Group A: TH17 cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 4, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7 - 10
Cycle 4, Group A: T-reg cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 4, Group A: T-reg cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 4, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7 - 10
Cycle 4, Group B : TH1 cells BEFORE single plasma exchange
Timeframe: Day 0, Hour 0
Cycle 4, Group B : TH1 cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 4, Group B : TH1 cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7 -10
Cycle 4, Group B : TH17 cells BEFORE single plasma exchange
Timeframe: Day 0, Hour 0
Cycle 4, Group B : TH17 cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 4, Group B : T17 cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7 -10
Cycle 4, Group B : T-reg cells BEFORE single plasma exchange
Timeframe: Day 0, Hour 0
Cycle 4, Group B : T-reg cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 4, Group B : T-reg cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7 - 10
Cycle 5, Group A : TH1 cells BEFORE single plasma exchange
Timeframe: Day 0, Hour 0
Cycle 5, Group A : TH1 cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 5, Group A : TH1 cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7 - 10
Cycle 5, Group A : TH17 cells BEFORE single plasma exchange
Timeframe: Day 0, Hour 0
Cycle 5, Group A : TH17 cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 5, Group A : TH17 cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7 - 10
Cycle 5, Group A : T-reg cells BEFORE single plasma exchange
Timeframe: Day 0, Hour 0
Cycle 5, Group A : T-reg cells AFTER single plasma exchange
Timeframe: Day 0, Hour 3
Cycle 5, Group A : T-reg cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7 - 10
Cycle 5, Group B : TH1 cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 5, Group B : TH1 cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 5, Group B : TH1 cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7-10
Cycle 5, Group B : TH17 cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 5, Group B : TH17 cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 5, Group B : TH17 cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7-10
Cycle 5, Group B : T-reg cells BEFORE double filtration plasmapheresis
Timeframe: Day 0, Hour 0
Cycle 5, Group B : T-reg cells AFTER double filtration plasmapheresis
Timeframe: Day 0, Hour 3
Cycle 5, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7-10
Cycle 6, Group A : TH1 cells BEFORE double filtration plasmapheresis
Timeframe: Day 0 Hour 0
Cycle 6, Group A : TH1 cells AFTER double filtration plasmapheresis
Timeframe: Day 0 Hour 3
Cycle 6, Group A : TH1 cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7-10
Cycle 6, Group A : TH17 cells BEFORE double filtration plasmapheresis
Timeframe: Day 0 Hour 0
Cycle 6, Group A : TH17 cells AFTER double filtration plasmapheresis
Timeframe: Day 0 Hour 3
Cycle 6, Group A : TH17 cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7-10
Cycle 6, Group A : T-reg cells BEFORE double filtration plasmapheresis
Timeframe: Day 0 Hour 0
Cycle 6, Group A : T-reg cells AFTER double filtration plasmapheresis
Timeframe: Day 0 Hour 3
Cycle 6, Group A : T-reg cells 7-10 days AFTER double filtration plasmapheresis
Timeframe: Day 7-10
Cycle 6, Group B : TH1 cells BEFORE single plasma exchange
Timeframe: Day 0 Hour 0
Cycle 6, Group B : TH1 cells AFTER single plasma exchange
Timeframe: Day 0 Hour 3
Cycle 6, Group B : TH1 cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7-10
Cycle 6, Group B : TH17 cells BEFORE single plasma exchange
Timeframe: Day 0 Hour 0
Cycle 6, Group B : TH17 cells AFTER single plasma exchange
Timeframe: Day 0 Hour 3
Cycle 6, Group B : TH17 cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7-10
Cycle 6, Group B : T-reg cells BEFORE single plasma exchange
Timeframe: Day 0 Hour 0
Cycle 6, Group B : T-reg cells AFTER single plasma exchange
Timeframe: Day 0 Hour 3
Cycle 6, Group B : T-reg cells 7-10 days AFTER single plasma exchange
Timeframe: Day 7-10