Active — Not RecruitingPhase 2/3

Efficacy of Magnesium Sulfate Bolus in Pediatric Patients With Bronchiolitis

United States40 participantsStarted 2021-07-21

Plain-language summary

The purpose of this study is to more rigorously evaluate the response to a single bolus of magnesium sulfate in a population of patients with moderate to severe bronchiolitis. The primary outcome will be to evaluate the effect of this therapy on clinical respiratory status. Secondary outcomes of interest will include the incidence of adverse effects and safety profile of magnesium bolus use in this population.

Who can participate

Age range1 Month – 12 Months

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Infants under 12 months of age * Admitted to the pediatric intensive care unit * Moderate/severe bronchiolitis using MPIS * Less than 24 hours of admission to the PICU * Parent/LAR consents for infant to participate Exclusion Criteria: * Patients with the following conditions are ineligible: chronic lung disease, unrepaired congenital heart disease, and cyanotic heart disease.

What they're measuring

To evaluate the effect of this therapy on clinical respiratory status

Timeframe: 6 hours post bolus of medication versus placebo

Trial details

NCT IDNCT04740294

SponsorUniversity of Louisville

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-30

View on ClinicalTrials.gov More Bronchiolitis, Viral trials