Assessing the Impact of Tixel Treatment of Periorbital Wrinkles on Dry Eye Symptoms and Signs

Inclusion Criteria: * Age ≥ 18 years * Mild to Moderate Periorbital wrinkles * OSDI score of at least 23 * Noninvasive Tear film break up time (NIKBUT) ≤ 10 seconds * No other eye or skin or immune problems * Willing and able to provide written informed consent. * Willing to participate in all study activities and instructions. Exclusion Criteria: * Pregnancy and/or breastfeeding * Lesions in the periorbital area * Acute severe blepharitis * Acute conjunctivitis * Other concomitant anterior eye disease * Has undergone outdoors/sunbed tanning during the last 4 weeks * Is unwilling to follow the Tixel aftercare instructions after each of the three Tixel treatments. * Active Herpes Simplex or tendency for Herpes Simplex in the periorbital area (meaning the subject has had the condition previously). * Current skin cancer, malignant sites and/or advanced premalignant lesions or moles in the treatment area. * An impaired immune system condition or use of immunosuppressive medication. * Collagen disorders, keloid formation and/or abnormal wound healing. * Previous invasive/ablative procedures in the areas to be treated within 3 months prior to initial treatment or plans for such treatment during the course of the Tixel2 device treatment, or before complete healing of such treatments has occurred. * Any patient who takes or has taken any medications (including via topical application), herbal treatment (oral or topic), food supplements or vitamins, which may cause fragile skin or …