CompletedNot Applicable

Brain Plus Spinal Stimulation for Cervical SCI

United States24 participantsStarted 2021-01-04

Plain-language summary

The goal of this project is to strengthen residual corticospinal tract (CST) connections after partial injury using combined motor cortex and spinal cord stimulation to improve arm and hand function after spinal cord injury (SCI). To do this, the investigators will test the combination of transcranial magnetic stimulation (TMS) with transcutaneous spinal direct current stimulation (tsDCS) in individuals with chronic cervical SCI.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion criteria

✓. Age between 18 and 75 years;
✓. No known central or peripheral neurological disease or injury.
✓. Age between 18 and 75 years;
✓. Chronic (\> 12 months) SCI between neurological levels C1-C8;
✓. Score of 2, 3, or 4 (out of 5) on manual muscle testing of elbow flexion, wrist extension, wrist flexion, finger extension, finger flexion, or finger abduction in left or right hand;

Exclusion criteria

✕. Multiple spinal cord lesions;
✕. History of seizures;
✕. Ventilator dependence or patent tracheostomy site;
✕. Use of medications that significantly lower seizure threshold, such as amphetamines, neuroleptics, dalfampridine, and bupropion;
✕. History of stroke, brain tumor, or brain abscess;
✕. History of moderate or severe head trauma (loss of consciousness for greater than one hour or evidence of brain contusion or hemorrhage or depressed skull fracture on prior imaging);
✕. History of implanted brain/spine/nerve stimulators, aneurysm clips, ferromagnetic metallic implants, or cardiac pacemaker/defibrillator;
✕. Significant coronary artery or cardiac conduction disease;

What they're measuring

Motor evoked potential (MEP) amplitudes

Timeframe: Change immediately after procedure

Trial details

NCT IDNCT04727866

SponsorBronx VA Medical Center

Sponsor typeFED

Study typeINTERVENTIONAL

Primary completion2024-01-12

View on ClinicalTrials.gov More Spinal Cord Injuries trials