CompletedNot Applicable

Biomarkers of Mortality and Morbidity in Children Hospitalized With Fever

Uganda2,500 participantsStarted 2012-02-01

Plain-language summary

The objective of this study is to identify clinically informative biomarkers of host defense pathways with potential utility as diagnostic and prognostic tools among children hospitalized with acute febrile illness in a resource-constrained sub-Saharan African setting. The working hypothesis is that a panel of biomarkers, readily measurable from a peripheral blood sample, may serve as a clinically useful instrument to distinguish between common pediatric causes of fever, predict those children at greatest need of aggressive supportive care and/or adjunctive therapies, and identify those children at greatest risk of mortality. The use of objective and quantitative tools may facilitate the triage and clinical care of febrile children admitted to hospital in the sub-Saharan African context.

Who can participate

Age range2 Months – 5 Years

SexALL

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Inclusion criteria

✓. Age 2 months to 5 years
✓. History of fever within past 48 hours or axillary temperature \>37.5°C
✓. Hospital admission warranted based on clinician judgment
✓. Consent to blood sampling and data collection

Exclusion criteria

✕. Outside eligible age range
✕. No history or objective evidence of fever
✕. Diarrheal illness without other symptoms
✕. Outpatient management
✕. Denial of consent to participate in study

What they're measuring

Mortality

Timeframe: through study completion, an average of 1 week

Trial details

NCT IDNCT04726826

SponsorUniversity of Alberta

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2013-09-15

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