TerminatedNot Applicable

Apraxia in Parkinson's Disease Patients With Deep Brain Stimulation

Stopped: Insufficient Enrollment

United States2 participantsStarted 2021-06-01

Plain-language summary

Deep brain stimulation (DBS) of the subthalamic nucleus or globus pallidus internus can improve motor symptoms Parkinson's disease (PD). However, it is not known whether DBS can help reduce the signs and symptoms of the limb-kinetic, ideomotor or ideational apraxia associated with PD or if apraxia can exist as a stimulation induced side effect from DBS therapy. In this study, we look to conduct a pilot study to examine the feasibility of characterizing the prevalence of apraxia in PD patients with chronic, stable DBS.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Patients with PD as defined by the UK Brain Bank Criteria
✓. Male or female, ages 18 to 80 years old
✓. Chronically implanted DBS of either the STN or GPi for a minimum of 6 months

Exclusion criteria

✕. Other neurological diagnoses (e.g. Alzheimer's disease, atypical parkinsonism, stroke)
✕. History of previous neurosurgical intervention that was not DBS
✕. Patients with DBS of targets other than the STN or GPi, or leads in both targets
✕. Patients in whom there is poor manual dexterity for a reason other than PD (e.g. orthopedic injury, amputation)
✕. Patients with a diagnosis of PD dementia

What they're measuring

Evaluate for the presence or absence of ideomotor apraxia in PD patients

Timeframe: Up to 1 hour

Evaluate for the presence or absence of ideational apraxia in PD patients

Timeframe: Up to 1 hour

Evaluate for the presence or absence of limb-kinetic apraxia in PD patients

Timeframe: Up to 30 minutes

Evaluate for the presence or absence of limb-kinetic apraxia in PD patients

Timeframe: Up to 30 minutes

Trial details

NCT IDNCT04725773

SponsorUniversity of Florida

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-01-28

View on ClinicalTrials.gov More Deep Brain Stimulation trials

Plain-language summary

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Patients with PD as defined by the UK Brain Bank Criteria
✓. Male or female, ages 18 to 80 years old
✓. Chronically implanted DBS of either the STN or GPi for a minimum of 6 months

Exclusion criteria

✕. Other neurological diagnoses (e.g. Alzheimer's disease, atypical parkinsonism, stroke)
✕. History of previous neurosurgical intervention that was not DBS
✕. Patients with DBS of targets other than the STN or GPi, or leads in both targets
✕. Patients in whom there is poor manual dexterity for a reason other than PD (e.g. orthopedic injury, amputation)
✕. Patients with a diagnosis of PD dementia

What they're measuring

Evaluate for the presence or absence of ideomotor apraxia in PD patients

Timeframe: Up to 1 hour

Evaluate for the presence or absence of ideational apraxia in PD patients

Timeframe: Up to 1 hour

Evaluate for the presence or absence of limb-kinetic apraxia in PD patients

Timeframe: Up to 30 minutes

Evaluate for the presence or absence of limb-kinetic apraxia in PD patients

Timeframe: Up to 30 minutes