Apraxia in Parkinson's Disease Patients With Deep Brain Stimulation (NCT04725773) | Clinical Trial Compass
TerminatedNot Applicable
Apraxia in Parkinson's Disease Patients With Deep Brain Stimulation
Stopped: Insufficient Enrollment
United States2 participantsStarted 2021-06-01
Plain-language summary
Deep brain stimulation (DBS) of the subthalamic nucleus or globus pallidus internus can improve motor symptoms Parkinson's disease (PD). However, it is not known whether DBS can help reduce the signs and symptoms of the limb-kinetic, ideomotor or ideational apraxia associated with PD or if apraxia can exist as a stimulation induced side effect from DBS therapy. In this study, we look to conduct a pilot study to examine the feasibility of characterizing the prevalence of apraxia in PD patients with chronic, stable DBS.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Patients with PD as defined by the UK Brain Bank Criteria
. Male or female, ages 18 to 80 years old
. Chronically implanted DBS of either the STN or GPi for a minimum of 6 months
Exclusion criteria
. Other neurological diagnoses (e.g. Alzheimer's disease, atypical parkinsonism, stroke)
. History of previous neurosurgical intervention that was not DBS
. Patients with DBS of targets other than the STN or GPi, or leads in both targets
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Evaluate for the presence or absence of ideomotor apraxia in PD patients
Timeframe: Up to 1 hour
2
Evaluate for the presence or absence of ideational apraxia in PD patients
Timeframe: Up to 1 hour
3
Evaluate for the presence or absence of limb-kinetic apraxia in PD patients
Timeframe: Up to 30 minutes
4
Evaluate for the presence or absence of limb-kinetic apraxia in PD patients