Early Life Stress and Depression: Molecular and Functional Imaging

Inclusion Criteria: * Females of all races and ethnic origins * Ages from 20 to 32 * Right-handed * Capable of providing written informed consent * Currently unmedicated. Note that this criterion applies at enrollment only, and subjects will be informed that they can continue to be in the study if they begin a new medication after enrollment. * Normal or corrected-to-normal vision and hearing * Fluency in written and spoken English * Absence of first-degree relatives with a history of a psychotic disorder or psychotic symptoms; (adopted individuals are eligible to participate but we will probe about family history in case such information is available to the adopted subject) Exclusion Criteria: * Participants with suicidal ideation where continued study participation is deemed unsafe by the study clinician (these participants will be immediately referred to appropriate clinical treatment) * Pregnant women, or women of childbearing potential who have a positive result on a urine pregnancy test * Failure to meet MRI safety requirements including but not limited to any metal implants or prostheses that cannot be removed, or exposure to shrapnel * Claustrophobia or severe anxiety that might impact participation in neuroimaging * Injury or movement disorder that may make it difficult to lie still in the scanner * Any current recreational/illicit drug use as assessed by a urine drug test (covering cocaine, cannabinoids, opiates, amphetamines, methamphetamines, phencyclidine, MDM…