Influence of Caffeinated and Non-caffeinated Pre-workout Supplements on Resistance Exercise Perfo… (NCT04712578) | Clinical Trial Compass
CompletedNot Applicable
Influence of Caffeinated and Non-caffeinated Pre-workout Supplements on Resistance Exercise Performance
United States24 participantsStarted 2021-02-23
Plain-language summary
This study is a randomized, double-blind, placebo-controlled crossover trial examining the effects of caffeinated and non-caffeinated pre-workout supplements on resistance exercise performance. Resistance-trained adults will be randomly assigned to complete three study conditions (caffeinated pre-workout, non-caffeinated pre-workout, and placebo) in one of the six possible condition orders. During each condition, participants will report to the laboratory for ingestion of the assigned beverage and subsequent muscular performance testing. Major performance outcomes will be force production variables from a mechanized squat device and maximal strength and muscular endurance on the bench press and leg press exercises.
Who can participate
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Between the ages of 18 and 40;
* Body mass between 50 - 100 kg (110-220 lb)
* Generally healthy (defined as an absence of any disease or medical condition which could potentially be negatively affected by consumption of the commercially available dietary supplements or performance of exercise, including but not limited to musculoskeletal or cardiovascular diseases).
* Resistance-trained, defined as completing 2+ resistance training sessions per week for at least three months prior to screening.
* Participants must have reported regular training of the lower body through a multi-joint exercise such as the squat or leg press at least once weekly during the three-month period prior to screening.
* Participants must have reported regular training of the bench press or chest press variation at least once weekly during the three-month period prior to screening.
* Female participants will be required to bench press ≥ 0.5 x body mass and leg press ≥ 1.75 x body mass during initial 1RM assessments to be eligible for this study.
* Male participants will be required to bench press ≥ 1.0 x body mass and leg press ≥ 3.0 x body mass to be eligible.
* Regular caffeine consumption (due to the presence of caffeine in the commercially available dietary supplement). This will be defined as an average self-reported daily intake of 250+ mg of caffeine, which is equivalent to approximately 2.5 cups of coffee.
Exclusion Criteria:
* Failing to meet any of the aforementioned …
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Isometric Peak Force Production
Timeframe: Approximately 35 minutes after beverage ingestion in each condition.
2
Isometric Rate of Force Development
Timeframe: Approximately 35 minutes after beverage ingestion in each condition.
3
Isokinetic Peak Concentric Force Production
Timeframe: Approximately 40 minutes after beverage ingestion in each condition.
4
Isokinetic Peak Eccentric Force Production
Timeframe: Approximately 40 minutes after beverage ingestion in each condition.
5
Maximal Strength on Bench Press Exercise
Timeframe: Approximately 65 minutes after beverage ingestion in each condition.
6
Muscular Endurance on Bench Press Exercise
Timeframe: Approximately 70 minutes after beverage ingestion in each condition.
7
Maximal Strength on Leg Press Exercise
Timeframe: Approximately 95 minutes after beverage ingestion in each condition.