Efficacy of N-acetylcysteine Versus Placebo as Prophylaxis of Sinusoidal Obstruction Syndrome in Patients Undergoing Hematopoietic Stem Cell Transplantation

Inclusion Criteria: * Men or women * Age ≥ 18 years * A proven diagnosis of one of the hematological malignancies: Acute Myeloid Leukemia, Acute Lymphoid Leukemia, Chronic Myeloid Leukemia, Chronic Lymphoid Leukemia, Multiple Myeloma, Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma * Patients must be scheduled to undergo of Allogeneic hematopoietic transplantation or HLA (Human Leukocyte Antigen) haploidentical related or Unrelated or HLA-matched related or autologous stem cell transplant * Patients must be able to understand and sign a written informed consent Exclusion Criteria: * Patient has a serious active disease or co-morbid medical condition, as judged by the investigator, which would interfere with the conduct of this study * Patient, in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study * Known hypersensitivity to N-acetylcysteine * Contraindications to perform any procedure provided for in this study * Patients who have already undergone a previous transplant