This study aims to understand the enteroendocrine physiological changes in superobese patients submitted to two different bariatric procedures (biliopancreatic diversion with duodenal switch versus single anastomosis duodeno-ileal bypass), when perfomed as primary or revisional surgeries (after a sleeve gastrectomy). The main purpose is to establish the metabolic changes obtained with the sleeve gastrectomy and how the revisional procedure maximizes those changes. Additionally, the study will determine whether BPD with DS or SADI-S is superior than the other as first choice for the superobese. The study will monitor the enteroendocrine function before and after the ingestion of a mixed meal, in pre-operatory and post-surgery timepoints, comparing both primary and revisional surgeries.
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Change in body mass index
Timeframe: From enrolment to 12 months post-intervention in 4 visits: preoperative, 3, 6 and 12 months post-surgery
Change in glycated haemoglobin
Timeframe: From enrolment to 12 months post-intervention in 4 visits: preoperative, 3, 6 and 12 months
Change in glucose dynamic profile
Timeframe: From enrolment to 12 months post-intervention in 4 visits: preoperative, 3, 6 and 12 months
Change in insulin dynamic profile
Timeframe: From enrolment to 12 months post-intervention in 4 visits: preoperative, 3, 6 and 12 months post-surgery
Change in glucagon dynamic profile
Timeframe: From enrolment to 12 months post-intervention in 4 visits: preoperative, 3, 6 and 12 months post-surgery
Change in GLP-1 dynamic profile
Timeframe: From enrolment to 12 months post-intervention in 4 visits: preoperative, 3, 6 and 12 months post-surgery
Change in GIP dynamic profile
Timeframe: From enrolment to 12 months post-intervention in 4 visits: preoperative, 3, 6 and 12 months post-surgery