Establishment of a Early Risk Model of ECMO in Children With ARDS

Inclusion Criteria: * Acute onset; within 7 days of clinical insult * Chest imaging (radiograph or computed tomography) findings of new infiltrates (unilateral or bilateral) consistent with acute parenchymal disease * Edema not fully explained by fluid overload or cardiac failure * May present as new acute lung disease in setting of chronic lung disease and/or heart disease * OI≥16 * Viral etiology is clear Exclusion Criteria: * Perinatal lung disease * Large intracranial bleed with mass effect or need for neurosurgical intervention * Hypoxic cardiac arrest without adequate CPR * Irreversible underlying cardiac or lung pathology (and not a transplant candidate) * Pulmonary hypertension and chronic lung disease * Chronic multiorgan dysfunction * Incurable malignancy * Allogenic bone marrow recipients with pulmonary infiltrates * Hepatic or renal failure * Pertussis infection in infants * Fungal pneumonia * Immunodeficiency