TerminatedNot Applicable

Electrophysiological Biomarkers in MTLE Patients.

Stopped: Lack of funding to secure effort for testing.

United States1 participantsStarted 2021-11-30

Plain-language summary

The investigators plan to enroll individuals with medical temporal lobe epilepsy who are undergoing surgical workup with clinically implanted intracranial electrodes. The study intends to administer computerized memory tasks and stimulation during the intracranial Electroencephalography (EEG) monitoring period.

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion criteria

✓. Provision of signed and dated informed consent form
✓. Male or female, aged 18-65
✓. Diagnosed with lesional or non-lesional mesial temporal (hippocampal) seizure onset confirmed on SEEG monitoring
✓. Implanted with depth electrodes for localization of seizure onset with multiple hippocampal electrode arrays

Exclusion criteria

✕. Any patient who is unwilling or unable to provide consent
✕. Women who are pregnant
✕. Patients under 18 years
✕. Incarcerated persons

What they're measuring

Change in Intracranial EEG Recording: Spectral Power From Baseline

Timeframe: Baseline, up to 6 weeks postintervention

Change in Intracranial EEG Recording: Synchrony From Baseline

Timeframe: Baseline, up to 6 weeks postintervention

Trial details

NCT IDNCT04710004

SponsorEmory University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-12-16

Results submitted2024-02-01

View on ClinicalTrials.gov More Mesial Temporal Lobe Epilepsy trials