RecruitingNot Applicable

University of Pittsburgh Brain Health Initiative

United States300 participantsStarted 2019-11-18

Plain-language summary

This project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehensive assessment of clinical, neuroimaging, and biomarker measures.

Who can participate

Age range29 Years – 59 Years

SexMALE

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Inclusion criteria

✓. Professional football retiree aged 29-59
✓. Played a minimum of 3 professional football seasons, with a minimum of 3 games in each season
✓. Fluent in English (translations are not available/validated for most neuropsychological tests)
✓. Age 29-59 male
✓. High school education or beyond
✓. Fluent in English (translations are not available/validated for most neuropsychological tests)

Exclusion criteria

✕. Played organized football beyond high school
✕. History of severe TBI
✕. Current unstable cardiovascular disorder
✕. Prior history of psychosis (such as schizophrenia), or other major neurological disorder that would interfere with testing, in the opinion of the primary investigator.
✕. Contraindication to MR imaging, such as ferrous metal, pacemakers, or concerns about claustrophobia

What they're measuring

Rates of Brain Health versus Cognitive Impairment

Timeframe: 1-week

Trial details

NCT IDNCT04708613

SponsorDavid Okonkwo, MD, PhD

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12

Contact for this trial

Kathryn L Edelman, MS

412-624-1077 dunfeekl@upmc.edu

View on ClinicalTrials.gov More Traumatic Brain Injury trials