This study aims to examine the inflammatory response mediated by MMP-8 (Matrix metalloproteinase-8 ) level in peri-implant sulcus fluid adjacent to screw-retained, cemented or using the Acuris-system fixed single implant crowns as well as changing of the marginal bone level within the first year after implant restoration. Furthermore periodontal parameters, patient satisfaction and possible occurring biological or technical complications will be evaluated.
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Change of marginal bone level
Timeframe: at baseline, 4 months after implant placement and 3, 6 and 12 months after restoration
Change of matrix metalloproteinase 8 level
Timeframe: 4 months after implant placement, 3, 6 and 12 months after integration of the implant crown