Community Dynamics of Malaria Transmission in Humans and Mosquitoes in Fleh-la and Marshansue, Sa… (NCT04704674) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Community Dynamics of Malaria Transmission in Humans and Mosquitoes in Fleh-la and Marshansue, Salala District, Bong County, Liberia
Liberia396 participantsStarted 2021-09-30
Plain-language summary
Background:
Malaria is a disease that affects many people in Liberia. It is caused by germs (parasites) that are spread by mosquito bites. Researchers want to gather data that may help them understand the best way to use a malaria vaccine in Liberia, which will be important in getting rid of the disease.
Objective:
To find out how often people of all ages who live in Fleh-la and Marshansue, Liberia, get malaria.
Eligibility:
Healthy people ages 6 months and older who live in Fleh-la and Marshansue in a household with adults and children.
Design:
Participants will be screened with a physical exam and questions about their health.
Participants will have monthly study visits. They will be asked about any symptoms of malaria and their use of bednets. Their vital signs, such as blood pressure and temperature, will be checked. Blood will be taken from the participant s arm or finger with a needle. If they have a fever, they will get a malaria test. If positive, they will get drugs to treat malaria.
Once a month, participants houses will be examined for mosquitoes. The team will remove all mosquitoes they collect. As part of this collection, participants houses will be sprayed with a chemical to kill mosquitoes and other insects. Participants will not be allowed in their house while the team is inside. The spray will not harm the participants.
Once a year, at the monthly visit, an additional blood sample will be taken.
Some of the participants blood samples will be used for genetic testing.
Participation will last for up to 3 years.
Who can participate
Age range
6 Months
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
* INCLUSION CRITERIA:
Subject Inclusion Criteria:
* 6 months of age and above
* Known resident of Fleh-la and Marshansue or the surrounding villages and planning to remain for duration of study
* Willingness to allow stored laboratory specimens to be used for future research
* Acceptance and signature of the written informed consent and the assent for children aged 12-17 years who are not otherwise emancipated
Household Inclusion Criteria:
To be eligible for participation, households must meet the following criteria:
* Household with at least 3 residents eligible for participation.
* Household with at least one compound member who is below 18 years of age whose parents or caretakers are willing to provide informed consent for the child to participate.
* Household members willing to accommodate mosquito sampling in their compound, both indoors and outdoors.
Exclusion Criteria:
Subject Exclusion Criteria:
* Behavioral, cognitive, or psychiatric disease that in the opinion of the investigator affects the ability of the subject to understand and cooperate with the study protocol.
* Other condition that, in the opinion of the investigator, would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Measurement of Monthly rates of blood smear positive individuals by age
Timeframe: one year
Trial details
NCT IDNCT04704674
SponsorNational Institute of Allergy and Infectious Diseases (NIAID)