CompletedNot Applicable

Identification of Pathophysiological Pathways and Therapeutic Targets in Primary Stomatodynia by Salivary Metabolomics

France53 participantsStarted 2021-03-10

Plain-language summary

Burning mouth syndrome (BMS) is defined by a chronic oral pain affecting especially postmenopausal women. Its physiopathology is still unknown and several hypotheses have been put forward to explain this syndrome, such as neurological, hormonal or inflammatory process. The recent development of salivary metabolomic profiling in oral diseases has led to the identification of potential pathways in such disorders. The aim of this study is to analyze the salivary metabolomic in BMS patients compared to healthy controls.

Who can participate

Age range18 Years

SexFEMALE

See this in plain English?

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Inclusion Criteria: * For cases : primary Burning Mouth Syndrome, based on the IHS diagnosis criteria * For cases : being able to realise the salivary collection * For controls : no primary BMS * For controls : being able to realise the salivary collection Exclusion Criteria for both groups: * Treatment by antibiotics in the previous month * New treatment in the previous two weeks * Active smoking * Active infectious or inflammatory oral disease * Systemic disease that could have an impact on the salivary metabolome or on the neurological system * Being under legal guardianship * Opposition to the processing of personal data

What they're measuring

Comparative analysis of salivary metabolomic profiles between cases (primary BMS) and controls

Timeframe: at inclusion

Trial details

NCT IDNCT04704128

SponsorUniversity Hospital, Tours

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-05-12

View on ClinicalTrials.gov More Primary Burning Mouth Syndrome trials