UnknownNot Applicable

Lens Extraction Combined With Goniosynechialysis Versus Trabeculectomy

China316 participantsStarted 2021-01-30

Plain-language summary

To compare the effectiveness of lens extraction combined with goniosynechialysis and trabeculectomy in treating advanced angle-closure glaucoma.

Who can participate

Age range

40 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Age between 40 years old to 80 years old
. more than 180-degree synechial closure of anterior chamber angle on gonioscopy
. IOP higher than 21mmHg under the use of more than two anti-glaucoma eye drops
. mean deviation of visual field worse than -12dB on Humphrey 24-2
. phakic eyes

Exclusion criteria

. Snellen visual acuity worse than 0.02
. history of ocular trauma
. uveitis
. previous ocular surgeries
. significant conjunctival scar
. visible neovascular on iris or anterior chamber angle
. other severe eye diseases that would affect visual function significantly, such as age-related macular degeneration and pathogenic myopia.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Intraocular pressure (IOP) change at one month

Timeframe: one month

IOP change at three months

Timeframe: three months

IOP change at six months

Timeframe: six months

IOP change at one year

Timeframe: one year

IOP change at two years

Timeframe: two years

IOP change at three years

Timeframe: three years

Best corrected visual acuity at one month

Timeframe: one month

Best corrected visual acuity at three months

Timeframe: three months

Trial details

NCT IDNCT04703712

SponsorEye & ENT Hospital of Fudan University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12

Contact for this trial

Feng Gao, Doctor

(86)021-64377134 fenggao@fudan.edu.cn

View on ClinicalTrials.gov More Glaucoma, Angle-Closure trials

Who can participate

Age range

40 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Age between 40 years old to 80 years old
. more than 180-degree synechial closure of anterior chamber angle on gonioscopy
. IOP higher than 21mmHg under the use of more than two anti-glaucoma eye drops
. mean deviation of visual field worse than -12dB on Humphrey 24-2
. phakic eyes

Exclusion criteria

. Snellen visual acuity worse than 0.02
. history of ocular trauma
. uveitis
. previous ocular surgeries
. significant conjunctival scar
. visible neovascular on iris or anterior chamber angle
. other severe eye diseases that would affect visual function significantly, such as age-related macular degeneration and pathogenic myopia.

What they're measuring

Intraocular pressure (IOP) change at one month

Timeframe: one month

IOP change at three months

Timeframe: three months

IOP change at six months

Timeframe: six months

IOP change at one year

Timeframe: one year

IOP change at two years

Timeframe: two years

IOP change at three years

Timeframe: three years

Best corrected visual acuity at one month

Timeframe: one month

Best corrected visual acuity at three months

Timeframe: three months